General Information

  • ID:  hor002788
  • Uniprot ID:  P58707
  • Protein name:  Antho-RNamide
  • Gene name:  NA
  • Organism:  Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)
  • Family:  NA
  • Source:  animal
  • Expression:  Neuron specific.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Anthopleura (genus), Actiniidae (family), Actiniaria (order), Hexacorallia (subclass), Anthozoa (class), Cnidaria (phylum), Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  FLRN
  • Length:  4(1-4)
  • Propeptide:  FLRN
  • Signal peptide:  NA
  • Modification:  T1 3-phenyllactic acid;T4 Asparagine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002788_AF2.pdbhor002788_ESM.pdb

Physical Information

Mass: 60233 Formula: C25H40N8O6
Absent amino acids: ACDEGHIKMPQSTVWY Common amino acids: FLNR
pI: 10.55 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 2
Hydrophobicity: -35 Boman Index: -1366
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 97.5
Instability Index: 8650 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  1973541
  • Title:  Isolation of L-3-phenyllactyl-Leu-Arg-Asn-NH2 (Antho-RNamide), a sea anemone neuropeptide containing an unusual amino-terminal blocking group.